Klonopin (Clonazepam) 0.25mg 250 Tablets by NRX | Sometimes to avoid custom issues, Tablets will be sent without bottle. is an anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of gamma-aminobutyric acid receptor responses. 
Mechanism of Action of ClonazepamClonazepam binds to the BZD receptor in the CNS. The binding will facilitate GABA mediated chloride channel opening and produce hyperpolarisation. This will result in an increase in the concentration of the inhibitory neurotransmitter GABA and decreases firing rate of neuron. This in turn alters normal functions of the body. Clonazepam also blocks Pentylenetetrazol which is responsible for seizure production and therefore Clonazepam is useful in the treatment of epilepsy.Pharmacokinets of Clonazepam
Absorption: It is well absorbed after oral administration. Distribution: It is distributed widely in the body in protein bound form. Metabolism: It is metabolised in the liver. Excretion: Most metabolites are excreted in urineOnset of Action for Clonazepam
20 - 60 minuteDuration of Action for Clonazepam
6 - 12 hourHalf Life of Clonazepam18 - 40 hourSide Effects of Clonazepam
1.Sedation   2.Dullness    3.Ataxia    4.Drowsiness    5.Behavioural changes    6.Amnesia    7.Lethargy    8.Nystagmus    9.Salivary secretion    10 Constipation    11.Gastritis 12.Enuresis    13.Dysuria    14.Somnolence    15.AnorexiaContra-indications of Clonazepam
1.Hypersensitivity to Benzodiazepines 2.Acute narrow angle glaucomaSpecial Precautions while taking Clonazepam
1.Renal impairment 2.Hepatic impairment 3.Pulmonary insufficiency 4.Mixed type seizure 5.Porphyria Pregnancy Related Information
ContraindicatedOld Age Related Information
Use with cautionBreast Feeding Related Information
ContraindicatedChildren Related Information
Use with caution NEONATES-contraindicated Indications for Clonazepam
1. Anticonvulsant in generalised tonic-clonic, Myoclonic, Status epilepticus and Absence seizures 2. Adjunct treatment in Schizophrenia 3. Neuralgia 4. severe anxietyTypical Dosage for Clonazepam
Adult: Anticonvulsant: Initial dose: 0.5 mg three times a day. The dose can be gradually increased by 0.5 - 1 mg up to 20 mg / day. Maintenance dose: 4 - 8 mg / day in 3- 4 divided doses Adjunct treatment in Schizophrenia: 0.5 - 2 mg at bed time Neuralgia: 2 - 4 mg / day Children: Anticonvulsant: Initial dose10 - 30 mcg / kg / day in 3 divided dose. The dose can be gradually increased up to 200 mcg / day. Schedule of Clonazepam
H DRUGStorage Requirements for Clonazepam
The drug should be kept at 15 - 30 degree C in a tightly closed container. Keep out of the reach of children.Effects of Missed Dosage of Clonazepam
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed doseEffects of Overdose of Clonazepam
Give supportive measures and symptomatic treatment. Gastric lavage has to be done. Flumazenil can be given as antagonist. Hypotension can be treated with vasopressors.Note :Do not start using a new medication without telling your doctor. It will affect you & your loved ones. Safety First. Please keep it in mindPrescription Only Medicine : These medicines are only available with a valid prescription from a licensed medical practitioner. Please be kind to send us the prescription by email, fax or standard mail with your order. All orders without an accompanying prescription will be rejected (see exceptions below). These measures are enforced as both a legal requirement as well as to ensure your safety.
However if you are unable to send us your prescription because of any reason, please let us know and we will accommodate your request.  Eg:

•     You have lost or misplaced your prescription
  
•     You have to present it to the local pharmacy to buy other drugs not available with us
  
•     You have received an online (eScript) prescription.